久热中文字幕无码视频,第一次互换人妻王静

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科學(xué)研究

蛋白質(zhì)組中心

蛋白質(zhì)組中心

陳涉博士

北京生命科學(xué)研究所高級研究員，蛋白質(zhì)組中心主任

Associate Investigator and Director of?Proteomics?Center, NIBS,Beijing,?China

電話： 010-80726688-8370

E-mail: chenshe@nibs.ac.cn

中心主任介紹：

陳涉研究員1995年于武漢大學(xué)獲得生物化學(xué)學(xué)士學(xué)位；1998年于中國科學(xué)院生物物理研究所獲得生物物理碩士學(xué)位；2000年于美國Iowa State University獲得食品科學(xué)碩士學(xué)位；2009年于北京師范大學(xué)獲得生物化學(xué)及分子生物學(xué)博士學(xué)位。2001年至2004年間分別于美國University of Texas Southwestern Medical Center at Dallas和美國MDS Proteomics Inc.公司從事蛋白質(zhì)生物質(zhì)譜技術(shù)工作。2004年回國建立北京生命科學(xué)研究所蛋白質(zhì)組中心并工作至今。2015年入選國家百千萬人才工程，并獲得國家有突出貢獻(xiàn)中青年專家稱號?，F(xiàn)任北京生命科學(xué)研究所高級研究員，蛋白組中心主任。

陳涉研究員致力于蛋白質(zhì)生物質(zhì)譜技術(shù)的開發(fā)和應(yīng)用，將生物質(zhì)譜技術(shù)運(yùn)用到包括病原體和宿主的相互作用、程序性細(xì)胞死亡、真核生物細(xì)胞表觀遺傳學(xué)信息的傳遞、晝夜節(jié)律的調(diào)控等眾多基礎(chǔ)生物學(xué)領(lǐng)域，取得了一系列重要成果，并發(fā)表在包括Nature, Science, Cell在內(nèi)的高水平國際期刊上。

北京生命科學(xué)研究所蛋白質(zhì)組中心簡介:

北京生命科學(xué)研究所蛋白質(zhì)組中心籌建于2004年，中心的核心組成部分為生物質(zhì)譜實(shí)驗(yàn)室，擁有Orbitrap Fusion Lumos、LTQ Orbitrap Velos、Q Exactive等多臺大型生物質(zhì)譜儀，為研究所各實(shí)驗(yàn)室提供高質(zhì)量的生物質(zhì)譜分析服務(wù)。服務(wù)內(nèi)容包括蛋白質(zhì)和多肽分子量測定，蛋白質(zhì)的鑒定，蛋白質(zhì)翻譯后修飾的分析與鑒定，復(fù)雜蛋白質(zhì)混合樣品的分析，以及蛋白質(zhì)組的比較定量研究。

中心在積極開發(fā)和完善各種先進(jìn)的生物質(zhì)譜分析技術(shù)的基礎(chǔ)上，致力于將這些技術(shù)有效的運(yùn)用到基礎(chǔ)生物學(xué)研究中去，幫助解決基礎(chǔ)生物學(xué)研究領(lǐng)域中的各個重大生物學(xué)問題。中心廣泛開展合作研究，根據(jù)各個具體生物學(xué)問題的需要開發(fā)和完善相應(yīng)的生物質(zhì)譜技術(shù)，加快這些生物學(xué)問題的解決，促進(jìn)基礎(chǔ)生物學(xué)研究領(lǐng)域的發(fā)展。

聯(lián)系方式：

北京生命科學(xué)研究所蛋白質(zhì)組中心

電話：010-80726688轉(zhuǎn)8372

傳真：010-80727513

地址：北京市昌平區(qū)中關(guān)村生命科學(xué)園科學(xué)園路七號

郵編：102206

中心現(xiàn)有生物質(zhì)譜儀:

Orbitrap Fusion Lumos質(zhì)譜儀	Q Exactive質(zhì)譜儀

LTQ Orbitrap Velos質(zhì)譜儀

中心部分署名文章:

1. Zhao, Y., Lin, L., Wang, X., He, S., Shi, W., Chen, S. (2022). Temporal Proteomic and Phosphoproteomic Analysis of EV-A71-Infected Human Cells. J. Proteome Res.
(https://doi.org/10.1021/acs.jproteome.2c00237)

2. Li, D., Chen, J., Guo, J., Li, L., Cai, G., Chen, S., Huang, J., Yang, H., Zhuang, Y., Wang, F., and Wang, X. (2021). A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2alpha-induced corpus luteum regression. eLife 10: e67409

3. Lyu, X., Yang, Q., Li, L., Dang, Y., Zhou, Z., Chen, S., and Liu, Y. (2020). Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape. PLoS Genet. 16(6): e1008836

4. Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., and Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nat. Commun. 10(1): 1199

5. Liu, J., Li, M., Li, L., Chen, S., and Wang, X. (2018). Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J. Cell Biol. 217(1): 347-360

6. Zhou, Y., Huang, C., Yin, L., Wan, M., Wang, X., Li, L., Liu, Y., Wang, Z., Fu, P., Zhang, N., Chen, S., Liu, X., Shao, F., and Zhu, Y. (2017). N(epsilon)-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science 358(6362): 528-531

7. Zhang, L., Wu, C., Cai, G., Chen, S., and Ye, K. (2016). Stepwise and dynamic assembly of the earliest precursors of small ribosomal subunits in yeast. Genes Dev. 30(6): 718-732

8. Li, D., Xu, T., Cao, Y., Wang, H., Li, L., Chen, S., Wang, X., and Shen, Z. (2015). A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc. Natl. Acad. Sci. U. S. A. 112(16): 5017-5022

9. Guo, B., Liang, Q., Li, L., Hu, Z., Wu, F., Zhang, P., Ma, Y., Zhao, B., Kovacs, A.L., Zhang, Z., Feng, D., Chen, S., and Zhang, H. (2014). O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nat. Cell Biol. 16(12): 1215-1226

10. Li, S., Zhang, L., Yao, Q., Li, L., Dong, N., Rong, J., Gao, W., Ding, X., Sun, L., Chen, X., Chen, S.^#, and Shao, F.^# (2013). Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature 501(7466): 242-246. ( ^#共同通訊作者).

11. Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., and Wang, X. (2012). Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. Cell 148(1-2): 213-227

12. Xu, M., Wang, W., Chen, S.^#, and Zhu, B.^# (2012). A model for mitotic inheritance of histone lysine methylation. EMBO Rep. 13(1): 60-67. (^#共同通訊作者).

13. Zhang, L., Ding, X., Cui, J., Xu, H., Chen, J., Gong, Y. N., Hu, L., Zhou, Y., Ge, J., Lu, Q., Liu, L., Chen, S., and Shao, F. (2011). Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation. Nature 481(7380): 204-208

14. Shang, L., Chen, S., Du, F., Li, S., Zhao, L., and Wang, X. (2011). Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc. Natl. Acad. Sci. U. S. A. 108(12): 4788-4793

15. Xu, M., Long, C., Chen, X., Huang, C., Chen, S.^#, and Zhu, B.^# (2010). Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 328(5974): 94-98. (^#共同通訊作者).

16. Cui, J., Yao, Q., Li, S., Ding, X., Lu, Q., Mao, H., Liu, L., Zheng, N., Chen, S., and Shao, F. (2010). Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 329(5996): 1215-1218

17. Tang, C. T., Li, S., Long, C., Cha, J., Huang, G., Li, L., Chen, S.^#, and Liu, Y.^# (2009). Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events. Proc. Natl. Acad. Sci. U. S. A. 106(26): 10722-10727. (^#共同通訊作者).

18. Huang, G.*, Chen, S.*, Li, S., Cha, J., Long, C., Li, L., He, Q., and Liu, Y. (2007). Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev. 21(24): 3283-3295. (*共同第一作者).

中心全部署名文章:

1. Zhu, X., Yang, N., Yang, Y., Yuan, F., Yu, D., Zhang, Y., Shu, Z., Nan, N., Hu, H., Liu, X., Chen, S., Sun, L., and Wang, H. (2022). Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development. Cell Res. 32(4): 407-410

2. Zhou, J.X., Su, X.M., Zheng, S.Y., Wu, C.J., Su, Y.N., Jiang, Z., Li, L., Chen, S., and He, X.J. (2022). The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis. J. Integr. Plant Biol. 64(4): 901-914

3. Yan, B., Ding, Z., Zhang, W., Cai, G., Han, H., Ma, Y., Cao, Y., Wang, J., Chen, S., and Ai, Y. (2022). Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. Cell Chem. Biol. 29(6): 958-969 e955

4. Qi, P.L., Zhou, H.R., Zhao, Q.Q., Feng, C., Ning, Y.Q., Su, Y.N., Cai, X.W., Yuan, D.Y., Zhang, Z.C., Su, X.M., Chen, S.S., Li, L., Chen, S., and He, X.J. (2022). Characterization of an autonomous pathway complex that promotes flowering in Arabidopsis. Nucleic Acids Res. 50(13): 7380-7395

5. Dou, C., Long, Z., Li, S., Zhou, D., Jin, Y., Zhang, L., Zhang, X., Zheng, Y., Li, L., Zhu, X., Liu, Z., He, S., Yan, W., Yang, L., Xiong, J., Fu, X., Qi, S., Ren, H., Chen, S., Dai, L., Wang, B., and Cheng, W. (2022). Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. Cell Res. 32(3): 302-314

6. Wu, C.J., Liu, Z.Z., Wei, L., Zhou, J.X., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). Three functionally redundant plant-specific paralogs are core subunits of the SAGA histone acetyltransferase complex in Arabidopsis. Mol. Plant 14(7): 1071-1087

7. Tan, M., Li, S., Juillard, F., Chitas, R., Custodio, T.F., Xue, H., Szymula, A., Sun, Q., Liu, B., Alvarez, A.L., Chen, S., Huang, J., Simas, J.P., McVey, C.E., and Kaye, K.M. (2021). MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res. 49(22): 12895-12911

8. Shang, J.Y., Lu, Y.J., Cai, X.W., Su, Y.N., Feng, C., Li, L., Chen, S., and He, X.J. (2021). COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis. Plant Cell 33(10): 3250-3271

9. Qian, F., Zhao, Q.Y., Zhang, T.N., Li, Y.L., Su, Y.N., Li, L., Sui, J.H., Chen, S., and He, X.J. (2021). A histone H3K27me3 reader cooperates with a family of PHD finger-containing proteins to regulate flowering time in Arabidopsis. J. Integr. Plant Biol. 63(4): 787-802

10. Liu, S., Liu, S., He, B., Li, L., Li, L., Wang, J., Cai, T., Chen, S., and Jiang, H. (2021). OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. EMBO reports 22(4): e51606

11. Li, D., Chen, J., Guo, J., Li, L., Cai, G., Chen, S., Huang, J., Yang, H., Zhuang, Y., Wang, F., and Wang, X. (2021). A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2alpha-induced corpus luteum regression. eLife 10: e67409

12. Hu, X., Li, Y., Zhang, T., Li, L., Chen, S., Wu, X., Li, H., Qi, B., and Chen, Z. (2021). Phosphorylation of Ago2 is required for its role in DNA double-strand break repair. J Genet. Genomics 48(4): 333-340

13. Guo, J., Wei, L., Chen, S.S., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. J. Integr. Plant Biol. 63(4): 755-771

14. Feng, C., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. J. Genet. Genomics 48(5): 369-383

15. Ao, K., Tong, M., Li, L., Ludke, D., Lipka, V., Chen, S., Wiermer, M., and Li, X. (2021). SCF(SNIPER7) controls protein turnover of unfoldase CDC48A to promote plant immunity. New Phytol. 229(5): 2795-2811

16. Zhou, S., Zhang, W., Cai, G., Ding, Y., Wei, C., Li, S., Yang, Y., Qin, J., Liu, D., Zhang, H., Shao, X., Wang, J., Wang, H., Yang, W., Wang, H., Chen, S., Hu, P., and Sun, L. (2020). Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Cell Res. 30(12): 1063-1077

17. Zhou, H.R., Lin, R.N., Huang, H.W., Li, L., Cai, T., Zhu, J.K., Chen, S., and He, X.J. (2020). The CCR4-NOT complex component NOT1 regulates RNA-directed DNA methylation and transcriptional silencing by facilitating Pol IV-dependent siRNA production. Plant J. 103(4): 1503-1515

18. Tan, L.M., Liu, R., Gu, B.W., Zhang, C.J., Luo, J., Guo, J., Wang, Y., Chen, L., Du, X., Li, S., Shao, C.R., Su, Y.N., Cai, X.W., Lin, R.N., Li, L., Chen, S., Du, J., and He, X.J. (2020). Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell 32(7): 2178-2195

19. Ning, Y.Q., Liu, N., Lan, K.K., Su, Y.N., Li, L., Chen, S., and He, X.J. (2020). DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation. Nat. Plants 6(8): 942-956

20. Lyu, X., Yang, Q., Li, L., Dang, Y., Zhou, Z., Chen, S., and Liu, Y. (2020). Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape. PLoS Genet. 16(6): e1008836

21. Luo, Y.X., Hou, X.M., Zhang, C.J., Tan, L.M., Shao, C.R., Lin, R.N., Su, Y.N., Cai, X.W., Li, L., Chen, S., and He, X.J. (2020). A plant-specific SWR1 chromatin-remodeling complex couples histone H2A.Z deposition with nucleosome sliding. EMBO J. 39(7): e102008

22. Li, D., Ai, Y., Guo, J., Dong, B., Li, L., Cai, G., Chen, S., Xu, D., Wang, F., and Wang, X. (2020). Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. eLife 9: e61564

23. Ju, D., Zhang, W., Yan, J., Zhao, H., Li, W., Wang, J., Liao, M., Xu, Z., Wang, Z., Zhou, G., Mei, L., Hou, N., Ying, S., Cai, T., Chen, S., Xie, X., Lai, L., Tang, C., Park, N., Takahashi, J.S., Huang, N., Qi, X., and Zhang, E.E. (2020). Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals. Sci. Transl. Med. 12(542)

24. Johnston, A.N., Ma, Y., Liu, H., Liu, S., Hanna-Addams, S., Chen, S., Chen, C., and Wang, Z. (2020). Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. Proc. Natl. Acad. Sci. U. S. A. 117(12): 6521-6530

25. Jiang, Z., Jin, X., Li, Y., Liu, S., Liu, X.M., Wang, Y.Y., Zhao, P., Cai, X., Liu, Y., Tang, Y., Sun, X., Liu, Y., Hu, Y., Li, M., Cai, G., Qi, X., Chen, S., Du, L.L., and He, W. (2020). Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells. Nat. Methods 17(9): 937-946

26. Jiang, X., Wang, X., Ding, X., Du, M., Li, B., Weng, X., Zhang, J., Li, L., Tian, R., Zhu, Q., Chen, S., Wang, L., Liu, W., Fang, L., Neculai, D., and Sun, Q. (2020). FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. EMBO J. 39(5): e102608

27. Hanna-Addams, S., Liu, S., Liu, H., Chen, S., and Wang, Z. (2020). CK1alpha, CK1delta, and CK1epsilon are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis. Proc. Natl. Acad. Sci. U. S. A. 117(4): 1962-1970

28. Gu, B.W., Tan, L.M., Zhang, C.J., Hou, X.M., Cai, X.W., Chen, S., and He, X.J. (2020). FHA2 is a plant-specific ISWI subunit responsible for stamen development and plant fertility. J. Integr. Plant Biol. 62(11): 1703-1716

29. Gao, L., Su, C., Du, X., Wang, R., Chen, S., Zhou, Y., Liu, C., Liu, X., Tian, R., Zhang, L., Xie, K., Chen, S., Guo, Q., Guo, L., Hano, Y., Shimazaki, M., Minami, A., Oikawa, H., Huang, N., Houk, K.N., Huang, L., Dai, J., and Lei, X. (2020). FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nat. Chem. 12(7): 620-628

30. Zhu, W., Li, J., Zhang, R., Cai, Y., Wang, C., Qi, S., Chen, S., Liang, X., Qi, N., and Hou, F. (2019). TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity. EMBO J. 38(18): e102075

31. Zhao, Q.Q., Lin, R.N., Li, L., Chen, S., and He, X.J. (2019). A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes. J. Integr. Plant Biol. 61(2): 120-139

32. Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., and Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nat. Commun. 10(1): 1199

33. Ning, Y.Q., Chen, Q., Lin, R.N., Li, Y.Q., Li, L., Chen, S., and He, X.J. (2019). The HDA19 histone deacetylase complex is involved in the regulation of flowering time in a photoperiod-dependent manner. Plant J. 98(3): 448-464

34. Li, D., Chen, J., Ai, Y., Gu, X., Li, L., Che, D., Jiang, Z., Li, L., Chen, S., Huang, H., Wang, J., Cai, T., Cao, Y., Qi, X., and Wang, X. (2019). Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol. Cell 75(6): 1103-1116 e1109

35. Fan, W., Guo, J., Gao, B., Zhang, W., Ling, L., Xu, T., Pan, C., Li, L., Chen, S., Wang, H., Zhang, J., and Wang, X. (2019). Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis. Sci. Signal. 12(583)

36. Ding, X., Jiang, X., Tian, R., Zhao, P., Li, L., Wang, X., Chen, S., Zhu, Y., Mei, M., Bao, S., Liu, W., Tang, Z., and Sun, Q. (2019). RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy 15(10): 1774-1786

37. Cheng, X., Ma, X., Zhu, Q., Song, D., Ding, X., Li, L., Jiang, X., Wang, X., Tian, R., Su, H., Shen, Z., Chen, S., Liu, T., Gong, W., Liu, W., and Sun, Q. (2019). Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol. Cell 73(4): 788-802 e787

38. Zhou, J.X., Liu, Z.W., Li, Y.Q., Li, L., Wang, B., Chen, S., and He, X.J. (2018). Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and regulate flowering time. J. Integr. Plant Biol. 60(5): 362-368

39. Ying, Z., Pan, C., Shao, T., Liu, L., Li, L., Guo, D., Zhang, S., Yuan, T., Cao, R., Jiang, Z., Chen, S., Wang, F., and Wang, X. (2018). Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury. Mol. Cell 72(3): 457-468 e455

40. Wang, J., Grubb, L.E., Wang, J., Liang, X., Li, L., Gao, C., Ma, M., Feng, F., Li, M., Li, L., Zhang, X., Yu, F., Xie, Q., Chen, S., Zipfel, C., Monaghan, J., and Zhou, J.M. (2018). A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Mol. Cell 69(3): 493-504 e496

41. Tan, L.M., Zhang, C.J., Hou, X.M., Shao, C.R., Lu, Y.J., Zhou, J.X., Li, Y.Q., Li, L., Chen, S., and He, X.J. (2018). The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing. EMBO J. 37(19)

42. Qin, J., Wang, K., Sun, L., Xing, H., Wang, S., Li, L., Chen, S., Guo, H.S., and Zhang, J. (2018). The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity. eLife 7: e34902

43. Qi, C., Wang, X., Shen, Z., Chen, S., Yu, H., Williams, N., and Wang, G. (2018). Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells. Cell Res. 28(5): 544-555

44. Luo, Y.X., Han, Y.F., Zhao, Q.Y., Du, J.L., Dou, K., Li, L., Chen, S., and He, X.J. (2018). Sumoylation of SUVR2 contributes to its role in transcriptional gene silencing. Science China. Life sciences 61(2): 235-243

45. Liu, W., Zhou, Y., Peng, T., Zhou, P., Ding, X., Li, Z., Zhong, H., Xu, Y., Chen, S., Hang, H.C., and Shao, F. (2018). N(epsilon)-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. Nat. Microbiol. 3(9): 996-1009

46. Liu, J., Li, M., Li, L., Chen, S., and Wang, X. (2018). Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J. Cell Biol. 217(1): 347-360

47. Liang, X., Ma, M., Zhou, Z., Wang, J., Yang, X., Rao, S., Bi, G., Li, L., Zhang, X., Chai, J., Chen, S., and Zhou, J.M. (2018). Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases. Cell Res. 28(5): 529-543

48. Dong, O.X., Ao, K., Xu, F., Johnson, K.C.M., Wu, Y., Li, L., Xia, S., Liu, Y., Huang, Y., Rodriguez, E., Chen, X., Chen, S., Zhang, Y., Petersen, M., and Li, X. (2018). Individual components of paired typical NLR immune receptors are regulated by distinct E3 ligases. Nat. Plants 4(9): 699-710

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