曹鵬 博士
- 基本信息
- 教育經歷
- 工作經歷
- 研究概述
- 發(fā)表文章
曹鵬博士北京生命科學研究所高級研究員
Peng Cao, Ph.D. Associate Investigator, NIBS, Beijing, China
Phone: 86-10-80726688-8535
Fax: 86-10-80726689
E-mail: caopeng@nibs.ac.cn
教育經歷
Education
2000年? 北京大學生命科學學院理學學士
B.Sc. Peking University, China
2005年 中國科學院生物物理研究所理學博士
Ph.D., Neurobiology, Institute of Biophysics, CAS
工作經歷
Professional Experience
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2022-Present |
北京生命科學研究所?高級研究員 |
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Associate Investigator, National Institute of Biological Sciences, Beijing |
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2016-2022年 |
北京生命科學研究所 研究員 |
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Assistant Investigator, National Institute of Biological Sciences, Beijing |
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2012-2016年 |
中國科學院生物物理研究所 研究員 |
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Principle Investigator, Institute of Biophysics, CAS |
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2008-2012年 |
美國斯坦福大學醫(yī)學院/霍華德休斯醫(yī)學研究所 助理研究員 |
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Research Associate, HHMI at Stanford University |
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2005-2008年 |
美國貝勒醫(yī)學院分子生理及生物物理系 博士后 |
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Postdoctoral Associate, Baylor College of Medicine |
研究概述
在《物種起源》中，達爾文提出＂適者生存＂的重要概念。＂適者生存＂的關鍵是成功應對生存威脅。微觀尺度上的生存威脅主要是病原微生物。它們可以入侵人和動物的消化道和呼吸道，引發(fā)一系列病理性的防御反應（如惡心和嘔吐）。宏觀尺度上的生存威脅主要是天敵。在面臨天敵威脅時，人和動物表現(xiàn)出一系列生理性防御反應（如戰(zhàn)斗和逃跑）。大腦如何感知這些不同尺度的生存威脅并啟動相應的防御反應，是神經科學領域一個重要的科學問題。我們實驗室以小鼠為動物模型，在微觀尺度上，研究了大腦啟動惡心和嘔吐的神經機制；在宏觀尺度上，研究了大腦啟動戰(zhàn)斗和逃跑的神經機制。
研究內容-1: 大腦感知病原入侵啟動防御反應的神經機制
食物中毒引發(fā)的惡心和嘔吐是機體自我保護的防御反應，對生存具有重要的意義。惡心和嘔吐也是癌癥化療的主要副作用，具有重要的臨床意義。在過去三十年里，惡心和嘔吐的機制研究一直舉步維艱，因為領域內缺乏合適的動物模型和研究范式。
2022年11月1日，我們在Cell上發(fā)表了題為The gut-to-brain axis for toxin-induced defensive responses的研究論文。該研究建立了以小鼠為動物模型研究惡心和嘔吐反應的新范式，發(fā)現(xiàn)腸道報告病原入侵的“情報員”細胞，迷走神經傳輸情報的“線人”細胞，以及腦內負責啟動惡心和嘔吐反應的“開關”細胞。在分子細胞層面上，揭示免疫反應和5-羥色胺信號在引發(fā)惡心和嘔吐中的重要功能，證明化療藥物是通過“綁架”這些分子細胞機制引發(fā)惡心和嘔吐的副作用。研究還發(fā)現(xiàn)，這些分子細胞和神經環(huán)路機制也參與了化療藥物（doxorubicin）引發(fā)的“惡心-嘔吐”副作用。這一發(fā)現(xiàn)暗示，化療藥物引發(fā)的“惡心-嘔吐”副作用，可能是通過綁架進化上保守的“食物中毒”機制得以實現(xiàn)。
同期的 Cell 配發(fā)了專家評論文章，對這一工作進行了詳細介紹。研究成果還被Nature Reviews Neuroscience以Research Highlight的形式進行了報道。紐約時報也對這一研究成果進行了采訪和報道。
研究內容-2:大腦感知天敵威脅啟動“戰(zhàn)斗-逃跑”反應的神經機制
人和動物在面臨生存威脅（例如天敵）時,可以表現(xiàn)出“戰(zhàn)斗-逃跑”行為反應，《水滸傳》中的武松打虎便是這一過程的生動范例。在某些人群中，過度或反復的“戰(zhàn)斗-逃跑”行為反應引發(fā)一類稱為創(chuàng)傷后壓力應激障礙（PTSD）的精神疾病。要揭示一類疾病的發(fā)病機制，往往需要從源頭入手分析。解析引發(fā)“戰(zhàn)斗”和“逃跑”行為反應的關鍵神經環(huán)路可能是深入分析PTSD發(fā)病機理的突破口。近年來,我們在這一研究方向上取得一系列研究成果。
我們在實驗室里建立了小鼠與天敵“戰(zhàn)斗”的行為范式，并發(fā)現(xiàn)天敵攻擊時產生的傷害性機械刺激是觸發(fā)小鼠戰(zhàn)斗行為的關鍵。我們在小鼠的下丘腦前核 AHN中發(fā)現(xiàn)編碼傷害性機械刺激的神經元。光激活這些神經元，能直接引發(fā)小鼠對抗天敵的防御行為。抑制這些神經元，小鼠失去了對抗天敵的能力。這一研究成果于2022年1月3日發(fā)表在Nature Neuroscience上。
大腦如何啟動“逃跑”的行為反應呢? 我們在小鼠的大腦中發(fā)現(xiàn)一群啟動逃避天敵行為的神經元。這些神經元位于一個叫做“上丘”的腦區(qū)，以小清蛋白（parvalbumin，PV）為生物標記物。上丘PV神經元可以像雷達一樣監(jiān)測天空中快速逼近的運動目標，并把這些預警信息傳送給恐懼中樞杏仁核。直接刺激該神經環(huán)路，可以快速引發(fā)強烈的逃跑行為。反復刺激該神經環(huán)路，動物出現(xiàn)類似PTSD的核心癥狀。這些科學發(fā)現(xiàn)于2015年6月26日發(fā)表在Science上。
以上關于“戰(zhàn)斗”和“逃跑”行為反應的神經機制的研究結果為進一步深入研究PTSD的發(fā)病機理奠定了重要基礎。
Representative Publications
1. Zhiyong Xie, Xianying Zhang, Miao Zhao, Lifang Huo, Meizhu Huang, Dapeng Li, Shuangfeng Zhang, Xingyu Cheng, Huating Gu, Chen Zhang, Cheng Zhan, Fengchao Wang, Congping Shang, Peng Cao. The gut-to-brain axis for toxin-induced defensive responses. Cell 185: 4298-4316 (2022)
● Cell, “A gut-retching discovery”.
● Nature Reviews Neuroscience, “Gut-brain pathways for toxin defence”.
● The New York Times, “How brains send a signal that it’s time to vomit”.
2. Zhiyong Xie, Dapeng Li, Xinyu Cheng, Qing Pei, Meizhu Huang, Huating Gu, Miao Zhao, Dandan Geng, Fan Zhang, Yuanwu Ma, Peng Cao. A brain-to-spinal neural circuit for repetitive self-grooming in mice. Neuron 110: 874-890 (2022)
● Neuron, “Of pride and groom: The gains and limits of studying the neuroanatomy of rodent self-grooming in translational research”.
3. Zhiyong Xie, Huating Gu, Meizhu Huang, Xingyu Cheng, Yuan Xie, Zongxiang Tang, Fan Zhang, Peng Cao. Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus. Nature Neuroscience 25: 72-85 (2022)
4. Congping Shang, Aixue Liu, Dapeng Li, Zhiyong Xie, Zijun Chen, Meizhu Huang, Yang Li, Yi Wang, Wei Shen, Peng Cao. A subcortical excitatory circuit for sensory-triggered predatory hunting in mice. Nature Neuroscience 22: 909-920 (2019)
● Nature Neuroscience, “Hungry for motion: the senses propel predation”
5. Zhihui Liu, Zijun Chen, Congping Shang, Fei Yan, Yingchao Shi, Jiajing Zhang, Baole Qu, Hailin Han, Yanying Wang, Dapeng Li, Thomas Südhof, Peng Cao. IGF1-dependent synaptic plasticity of mitral cells in olfactory memory during social learning. Neuron 95: 106-122 (2017)
6. Congping Shang, Zhihui Liu, Zijun Chen, Yingchao Shi, Su Liu, Dapeng Li, Qian Wang, Peng Cao. A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice. Science 348: 1472-77 (2015)
Other Publications
7. Ming-Ming Zhang, An-Qi Geng, Kun Chen, Jian Wang, Pan Wang, Xin-Tong Qiu, Jun-Xiang Gu, Hong-Wei Fan, Da-Yu Zhu, Shan-Ming Yang, Qi-Yu Chen, Zhao-Xiang Zhou, Bo-Yuan Fan, Yang Bai, Ke-Ke Xing, Jia-Ming Feng, Jun-Da Wang, Yan Chen, Ya-Cheng Lu, Ying Liang, Peng Cao, Bong-Kiun Kaang, Min Zhuo, Yun-Qing Li, Tao Chen. Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain. Neuron 110: 1993-2008.e6. (2022)
8. Jing-Jing Yan, Xiao-Jing Ding, Ting He, Ai-Xiao Chen, Wen Zhang, Zi-Xian Yu, Xin-Yu Cheng, Chuan-Yao Wei, Qiao-Dan Hu, Xiao-Yao Liu, Yan-Li Zhang, Mengge He, Zhi-Yong Xie, Xi Zha, Chun Xu, Peng Cao, Haohong Li, Xiao-Hong Xu. A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance. Nature Communications 13 (1), 1-16 (2022)
9. Yuan Wang, Rong Huang, Zuying Chai, Changhe Wang, Xingyu Du, Yuqi Hang, Yongxin Xu, Jie Li, Xiaohan Jiang, Xi Wu, Zhongjun Qiao, Yinglin Li, Bing Liu, Xianying Zhang, Peng Cao, Feipeng Zhu, Zhuan Zhou Calcium-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Reports 23 (11), e54507 (2022)
10. Meizhu Huang, Dapeng Li, Xinyu Cheng, Qing Pei, Zhiyong Xie, Huating Gu, Xuerong Zhang, Zijun Chen, Aixue Liu, Yi Wang, Fangmiao Sun, Yulong Li, Jiayi Zhang, Miao He, Yuan Xie, Fan Zhang, Xiangbin Qi, Congping Shang, Peng Cao. The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice. Nature Communications 12: 4409 (2021)
11. Zhiyong Xie, Mengdi Wang, Zeyuan Liu, Congping Shang, Changjiang Zhang, Le Sun, Huating Gu, Gengxin Ran, Qing Pei, Qiang Ma, Meizhu Huang, Junjing Zhang, Rui Lin, Youtong Zhou, Jiyao Zhang, Miao Zhao, Minmin Luo, Qian Wu, Peng Cao, Xiaoqun Wang. Transcriptomic encoding of sensorimotor transformation in the midbrain. eLife 10: e69825 (2021)
12. Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai, Qinghua Liu. Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia. Nature Communications 12: 2648 (2021)
13. Chaojuan Yang, Yonglu Tian, Feng Su, Yangzhen Wang, Mengna Liu, Hongyi Wang, Yaxuan Cui, Peijiang Yuan, Xiangning Li, Anan Li, Hui Gong, Qingming Luo, Desheng Zhu, Peng Cao, Yunbo Liu, Xunli Wang, Min-hua Luo, Fuqiang Xu, Wei Xiong, Liecheng Wang, Xiang-yao Li, Chen Zhang. Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome. Protein & Cell (2021)
14. Shiwei Qiu, Weihao Zhao, Xue Gao, Dapeng Li, Weiqian Wang, Bo Gao, Weiju Han, Shiming Yang, Pu Dai, Peng Cao, Yongyi Yuan. Syndromic deafness gene ATP6V1B2 controls degeneration of spiral ganglion neurons through modulating proton flux. Frontiers in Cell and Developmental Biology 9: 742714 (2021).
15. Jing Chen, Mingxiu Cheng, Liang Wang, Lei Zhang, Dan Xu, Peng Cao, Fengchao Wang, Herbert Herzog, Sen Song, Cheng Zhan. A Vagal-NTS neural pathway that stimulates feeding. Current Biology 30: 3986-3998.e5. (2020)
16. Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li, Wei Shen. Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nature Neuroscience 22: 921-932 (2019)
17. Congping Shang, Zijun Chen, Aixue Liu, Yang Li, Jiajing Zhang, Baole Qu, Fei Yan, Yaning Zhang, Weixiu Liu, Zhihui Liu, Xiaofei Guo, Dapeng Li, Yi Wang, Peng Cao. Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice. Nature Communications 9: 1232 (2018)
18. Yonglu Tian, Chaojuan Yang, Yaxuan Cui, Feng Su, Yongjie Wang, Yangzhen Wang, Peijiang Yuan, Shujiang Shang, Hao Li, Jizong Zhao, Desheng Zhu, Shiming Tang, Peng Cao, Yunbo Liu, Xunli Wang, Liecheng Wang, Wenbo Zeng, Haifei Jiang, Fei Zhao, Minhua Luo, Wei Xiong, Zilong Qiu, Xiang-Yao Li, Chen Zhang, An excitatory neural assembly encodes short-term memory in the prefrontal cortex. Cell Reports 22: 1734-1744 (2018)
19. Peng Cao, Xiaofei Yang, and Thomas Südhof, Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins. The Journal of Neuroscience 33: 1714-1727 (2013)
20. Xiaofei Yang, Peng Cao and Thomas Südhof. Deconstructing Complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. PNAS 110: 20777-20782 (2013)
21. Peng Cao, Anton Maximov, and Thomas Südhof, Activity-dependent IGF1 exocytosis is controlled by the Ca2+-sensor synaptotagmin 10. Cell 145: 300–311 (2011).
● Cell, “An exciting calcium sensor for smell”.
● Nature Reviews Neuroscience, “Molecular neuroscience: Synaptotagmin 10-mediated release”.
22. Zhiping Pang, Wei Xu, Peng Cao and Thomas Südhof. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Journal of Biological Chemistry 285: 33930-33939 (2010)
23. Zhiping Pang, Peng Cao, Wei Xu and Thomas Südhof. Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. The Journal of Neuroscience 30: 4132-4142 (2010)
24. Yan Yang, Peng Cao, Yang Yang, and Shu-Rong Wang, Corollary discharge circuits for saccadic modulation of the pigeon visual system. Nature Neuroscience 11: 595-602 (2008)
25. Daoying Hu, Peng Cao, Edda Thiels, Charleen Chu, Gang-Yi Wu, Tim Oury, Eric Klann. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiology of Learning and Memory 87: 372-384 (2007)
26. Peng Cao, Yan Yang, Yang Yang and Shu-Rong Wang. Differential modulation of thalamic neurons by optokinetic nuclei in the pigeon. Brain Research 1069: 159-165 (2006)
27. Peng Cao, Yong Gu, and Shu-Rong Wang, Visual neurons in the pigeon brain encode the acceleration of stimulus motion. The Journal of Neuroscience 24: 7690–7698 (2004)
28. Quan Xiao, Peng Cao, Yong Gu and Shu-Rong Wang Visual responses of neurons in the pretectal nucleus lentiformis mesencephali to moving patterns within and beyond receptive fields in pigeons. Brain Behavior and Evolution 57: 80-86 (2001)
Reviews and Previews
29. Zhihui Liu, Peng Cao. Love or not? A new subpopulation of neurons controls the switch of female sexual behavior. Neuron 110: 2893-2895 (2022)
30. Wei Xiao, Zhuo-Lei Jiao, Esra Senol, Jiwei Yao, Miao Zhao, Zheng-Dong Zhao, Xiaowei Chen, Peng Cao, Yu Fu, Zhihua Gao, Wei L Shen, Xiao-Hong Xu. Neural circuit control of innate behaviors. Science China Life Sciences 65: 466–499 (2022)
31. Xue Liu, Hongren Huang, Terrance P Snutch, Peng Cao, Liping Wang, Feng Wang. The superior colliculus: cell types, connectivity, and behavior. Neuroscience Bulletin 38: 1519–1540 (2022)
