李超博士
- 基本信息
- 教育經(jīng)歷
- 工作經(jīng)歷
- 研究概述
- 發(fā)表文章
李超博士
北京生命科學(xué)研究所高級(jí)研究員
Chao Li, Ph.D. Associate Investigator, NIBS, Beijing, China
Phone: 86-10-80726688
Fax: 86-10-80726689
E-mail: lichao@nibs.ac.cn
實(shí)驗(yàn)室主頁(yè)：http://www.lichaolab.com
教育經(jīng)歷 Education
2013 北京生命科學(xué)研究所與天津大學(xué)聯(lián)合培養(yǎng)有機(jī)合成化學(xué)博士
Ph.D. in Organic Synthesis, National Institute of Biological Science (NIBS), Beijing & Tianjin University, Tianjin, China.
2008 青島科技大學(xué)制藥工程學(xué)士
B.S., Pharmaceutical Engineering, Qingdao University of Science and Technology, Qingdao, China
工作經(jīng)歷 Professional Experience
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2023-Present |
北京生命科學(xué)研究所 高級(jí)研究員 |
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Associate Investigator, National Institute of Biological Sciences, Beijing |
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2017-2023年 |
北京生命科學(xué)研究所 研究員 |
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Assistant Investigator, National Institute of Biological Sciences, Beijing |
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2014-2017年 |
美國(guó)斯克里普斯研究所博士后 |
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Postdoctoral Research Fellow, The Scripps Research Institute, CA, USA |
研究概述 Research
Description
化學(xué)小分子在認(rèn)知，干擾與調(diào)節(jié)生物過(guò)程中發(fā)揮著重要的作用。我們課題組致力于在開拓合成化學(xué)空間的基礎(chǔ)上，利用獲得的活性小分子發(fā)現(xiàn)與人類重大疾病相關(guān)的藥物作用靶標(biāo)和先導(dǎo)化合物。同時(shí)設(shè)計(jì)合成具有重要生物學(xué)利用價(jià)值的化學(xué)工具分子。具體的研究?jī)?nèi)容包括：
（1）利用新型催化體系研究新穎的化學(xué)鍵構(gòu)建方法，為化學(xué)分子的合成提供更理想的策略。
（2）選擇與重大疾病相關(guān)的天然產(chǎn)物進(jìn)行合成及活性優(yōu)化，進(jìn)而推動(dòng)創(chuàng)新藥物的研究;
（3）探索活性天然小分子的生物學(xué)作用機(jī)制和其作用靶標(biāo);
（4）設(shè)計(jì)合成能夠選擇性標(biāo)記，追蹤生物大分子或識(shí)別其相互作用的化學(xué)工具分子。
我們實(shí)驗(yàn)室誠(chéng)摯地歡迎想利用化學(xué)手段解決生物學(xué)問(wèn)題的科學(xué)家加入。
Small molecules are of paramount importance in the recognition,
modulation and regulation of biological processes. The research of our group
explores the interface between chemical synthesis and biology, by pursuing the
efficient synthesis of structurally novel and therapeutically potent small
molecules prior to probing their mechanism of action and functional targets.
Our specific research interests include the following:
? Development of new catalytic reactions for the efficient
construction of chemical bonds, thereby providing practical synthetic methods
for “ideal synthesis”.
? Total synthesis of structurally complex and bioactive natural
products.
? Exploring the mechanism of action and the functional targets of
bioactive small molecules.
? Development of novel molecular probes to study the interactions
between biological macromolecules.
代表文章Representative Publications
19. Li, Z.; Sun, W.; Wang, X.; Li, L; Zhang, Y.; Li, C.* “Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides” J. Am. Chem. Soc. 2021, 143, 3536-3543.
18. Xu, G.#; Wu, J.#; Li, L.; Lu, Y.; Li, C.* “Total Synthesis of (-)-Daphnezomines A and B” J. Am. Chem. Soc. 2020, 142, 15240-15245.
17. Zhuo, J.#; Zhang, Y.#; Li, Z.; Li, C.* “Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles”. ACS Catal. 2020, 10, 3895-3903.
16.Zhang, J.#; Li, Z.#; Zhuo, J.; Cui, Y.; Han, T.; Li, C.* “Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin” J. Am. Chem. Soc. 2019, 141, 8372-8380.
15. Li, C.#; Kawamata, Y.#; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Star, J. T.; Chen, J.; Yan, M.; Baran, P. S.* “Electrochemically Enabled, Ni-Catalyzed Amination” Angew. Chem. Int. Ed. 2017, in press
14. Li, C.#; Wang, J.#; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.* “Decarboxylative Borylation” Science, 2017, 356, 1045.
13. Qin, T.#; Cornella, J.#; Li, C.#; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S.* “A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents” Science 2016, 352, 801-805
12. Li, C.; Jones, A. X.; Lei, X.* “Synthesis and Mode of Action of Oligomeric Sesquiterpene Lactones” Nat. Prod. Rep. 2016, 33, 602-611.
11. Li, D.#; Li, C.#; Li, L.; Chen, S.; Wang, L.; Li, Q.; Wang, X.; Lei, X.*; Shen, Z.* “Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis” Cell Chemical Biology 2016, 23, 257-266.
10. Hong, B.#; Li, C.#; Wang, Z.; Chen, J.; Li, H.*; Lei, X.* “Enantioselective Total Synthesis of (?)-Incarviatone A” J. Am. Chem. Soc. 2015, 137, 11946-11949.
9. Dao, H. T.; Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S.* “Hydromethylation of Unactivated Olefins” J. Am. Chem. Soc. 2015, 137, 8046-8049.
8. Dong, T. #; Li, C. #; Wang, X.; Dian, L.; Zhang, X.; Li, L.; Chen, S.; Cao, R.; Li, L.; Huang, N.; He, S.;* Lei, X.* “Ainsliadimer A Selectively Inhibits IKKα/β by Covalently Binding a Conserved Cysteine” Nature Commun. 2015, 6, 6522.
7. Li, C.#; Dong, T.#; Li, Q.; Lei, X.* “Probing the Anticancer Mechanism of (?)-Ainsliatrimer?A through Diverted Total Synthesis and Bioorthogonal Ligation” Angew. Chem. Int. Ed. 2014, 53, 12111-12115.
6. Li, C.; Lei, X.* “Strategies toward the Biomimetic Syntheses of Oligomeric Sesquiterpenoids” J. Org. Chem. 2014, 79, 3289-3295.
5. Li, C.; Dong, T.; Dian, L.; Zhang, W.; and Lei, X.* “Biomimetic Syntheses and Structural Elucidation of the Apoptosis-Inducing Sesquiterpenoid Trimers: (-)-Ainsliatrimers A and B” Chem. Sci. 2013,4, 1163-1167.
4. Li, C.; Li, X.; Wang, X.; Lei, X.* “Diversity-oriented Synthesis of Bicyclic Ring Systems via a Conjugate Addition/aldol/RCM Process” Sci. China. Chem. 2013, 56, 337-341.
3. Li, C.; Dian, L.; Zhang, W.; Lei, X.* “Biomimetic Syntheses of (-)-Gochnatiolides A-C and (-)-Ainsliadimer B” J. Am. Chem. Soc. 2012, 134, 12414-12417.
2. Li, C.; Tu, S.; Wen, S.; Li, S.; Chang, J.; Shao, F, Lei, X.* “Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C” J. Org. Chem. 2011, 76, 3566-3570.
1. Li, C.; Yu, X.; Lei, X.* “A Biomimetic Total Synthesis of (+)-Ainsliadimer A” Org. Lett. 2010, 12, 4284-4287.
專利Patents
1. Lei, X.; He, S.; Li, C.; Dong, T. “Sesquiterpenoids” PCT/CN2014/076123. US Pat No. 9670226.
2. Baran, P. S.; Li, C.; Wang, J.; Chatterjee, A. K.; Kumar, M.; Yu, S.; Johnson, K. A.; “Decarboxylative Borylation” under review.
