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齊湘兵博士 高級(jí)研究員，化學(xué)中心主任

Xiangbing Qi, Ph.D.

Associate Investigator and Director of Chemistry Center, NIBS, Beijing，China

電話： 010--80726688轉(zhuǎn)8655

傳真： 010-8070-8048

E-mail:qixiangbing@nibs.ac.cn

Homepage:http://qigroup.nibs.ac.cn/

教育經(jīng)歷

Education

2005-2009年? ? 美國(guó)德州大學(xué)西南醫(yī)學(xué)中心生物化學(xué)系，有機(jī)化學(xué)博士
Ph.D. Organic Chemistry，Department of Biochemistry，University of Texas Southwestern Medical Center at Dallas
2001-2004年? ? 同濟(jì)大學(xué)有機(jī)化學(xué)碩士
M.S. Organic Chemistry, Department of Chemistry, Tongji University
1997-2001年? ? 濟(jì)南大學(xué)應(yīng)用化學(xué)學(xué)士
B.S. Applied Chemistry, School of Chemistry and Chemical Engineering, University of Jinan

工作經(jīng)歷

Professional Experience

2021年-? ? ? 北京生命科學(xué)研究所高級(jí)研究員
Associate Investigator, National Institute of Biological Sciences, Beijing, China
2013年-? ? ? 北京生命科學(xué)研究所化學(xué)中心主任
Director of Chemistry Center, National Institute of Biological Sciences, Beijing, China
2010-2013年? ? 美國(guó)德州大學(xué)西南醫(yī)學(xué)中心，有機(jī)化學(xué)與藥物化學(xué)博士后
Postdoctoral Fellow, Organic Chemistry and Medicinal Chemistry, Department of Biochemistry，University of Texas Southwestern Medical Center at Dallas.
2009-2010年? ? 美國(guó)伊利諾伊大學(xué)厄巴納-香檳分校，有機(jī)化學(xué)博士后
Postdoctoral Fellow, Organic Chemistry，Department of Chemistry，University of Illinois at Urbana-Champaign.
2004-2005年? ? 中科院上海有機(jī)所，有機(jī)合成/藥物研發(fā)研究助理
Research Assistant, Organic synthesis/Medicinal chemistry，Shanghai Institute of Organic Chemistry, Chinese Academy of Science.

北京生命科學(xué)研究所化學(xué)中心為研究所的各實(shí)驗(yàn)室提供專業(yè)的化學(xué)服務(wù)并與生物實(shí)驗(yàn)室緊密合作開展前沿交叉課題，基于生物基礎(chǔ)研究進(jìn)展，結(jié)合現(xiàn)代藥物研發(fā)的最新技術(shù)手段包括高通量篩選以及計(jì)算機(jī)輔助設(shè)計(jì)等開發(fā)全新的生物醫(yī)藥靶點(diǎn)，并通過(guò)化學(xué)小分子探究與調(diào)控重要的生物學(xué)途徑。我們課題組核心部分主要包括：化學(xué)合成實(shí)驗(yàn)室，分析檢測(cè)實(shí)驗(yàn)室和高通量篩選實(shí)驗(yàn)室。目前實(shí)驗(yàn)室研究方向主要有原子經(jīng)濟(jì)學(xué)有機(jī)合成方法學(xué)開發(fā)，天然產(chǎn)物高效或仿生全合成，利用化學(xué)生物學(xué)新策略探索小分子與靶點(diǎn)的相互作用鑒定藥物新靶點(diǎn)與重要的生物學(xué)機(jī)理，以及基于新靶點(diǎn)的小分子藥物開發(fā)。實(shí)驗(yàn)室開發(fā)了新穎的烷基鋯廣譜偶聯(lián)合成方法學(xué)，首次發(fā)現(xiàn)了烷基鋯試劑的光化學(xué)與新型自由基偶聯(lián)反應(yīng)途徑；首次完成硼元素導(dǎo)向的烷基鋯選擇性遠(yuǎn)程遷移控制并應(yīng)用到高對(duì)映選擇性手性硼試劑的合成中?；谧匀唤缲S富的天然原材料如呋喃，吲哚，單糖以及天然氨基酸等，通過(guò)分子骨架重排或者去平面化策略成功構(gòu)建了以sp3雜化原子為主的三維立體“優(yōu)勢(shì)藥效骨架”并應(yīng)用到高生物活性的天然產(chǎn)物的全合成和仿生合成中；基于高通量篩選鑒定苗頭化合物，結(jié)合構(gòu)效關(guān)系和計(jì)算機(jī)輔助藥物設(shè)計(jì)進(jìn)行系統(tǒng)的藥物化學(xué)開發(fā)了幾類尚未滿足臨床需求的原創(chuàng)新藥備選分子,如抑制乙肝病毒感染的膽酸二聚體，調(diào)節(jié)生物鐘和睡眠的蟲草素衍生物以及癌癥治療相關(guān)的激酶抑制劑和誘導(dǎo)蛋白降解或者介導(dǎo)蛋白蛋白相互作用的分子膠水等。我們將緊密地把有機(jī)合成，藥物化學(xué)，化學(xué)生物學(xué)與生命科學(xué)相結(jié)合，從而為北京生命科學(xué)研究所建立起一套完善的化學(xué)合成與創(chuàng)新型藥物研發(fā)平臺(tái)。

Selected Publications（代表性文章）

1. Xiangbing Qi*, Wenhui Li*, “Unlocking the secrets to human NTCP structure” The Innovation, 10029

2. Chao Yang, Songlin Bai, and Xiangbing Qi*, “Asymmetric synthesis alkylboranes via enantioselective cross-coupling of gem-Borazirconocene Alkanes”, manuscript in revision.

3. Peihao Chen, Jing Wang, and Xiangbing Qi*, “Total Syntheses of Tetrodotoxin”, manuscript in revision.

4. Xiaolei Liu, Mingliang Lou, and Xiangbing Qi*, “Asymmetric Total Syntheses of Strychnos Alkaloids via Selective Fischer Indolization”，Journal of Organic Chemistry, 2022, 87 (8), 5199-5212

5. Yan Ma*, Yang Cao, Xiaocui Song, Yuanying Zhang, Jing Li, Yankai Wang, Xiaoqing Wu, and Xiangbing Qi, “BAFinder: A software for unknown bile acid identification using accurate mass LC-MS/MS in positive and negative modes”, Analytical Chemistry 2022, 94 (16), 6242-6250

6. Daojiang Yan, Kunya Wang, Songlin Bai, Bingyu Liu, Jian Bai, Xiangbing Qi, Youcai Hu, “Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine” J. Am. Chem. Soc., 2022, 144, 9, 4269-4276

7. Yue Liu, Songlin Bai, Yuanbo Du, Xiangbing Qi*, Hongyin Gao*, “Expeditious and Efficient ortho-Selective Trifluoromethane-sulfonylation of Arylhydroxylamines” Angew. Chem. Int. Ed., 2022, 61, e202115611

8. Gen Li, Mingliang Lou, Xiangbing Qi*, “A brief overview of classical natural product drug synthesis and bioactivity”, Organic Chemistry Frontiers, 2022, 9, 517-571

9. Jie Chen, Nan Liu, Yinpin Huang, Yuanxun Wang, Yuxing Sun, Hong-Wei Wang*, Niu Huang*, Xiangbing Qi* and Xiaodong Wang* “Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells”, Nature Communications, 2021, 12:6204 | https://doi.org/10.1038/s41467-021-26546-8

10. Chao Yang, Chao Jiang, Xiangbing Qi*, “Alkylzirconocenes in Organic Synthesis: An Overview”, Synthesis 2021; 53(06): 1061-1076

11. Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqiang Wang, Xiaofan Liu, Xuyan Shi, Yaxin Liu, Xiangbing Qi, Xiaoyun Liu*, Jingjin Ding, Feng Shao* “Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11”, Nature, 2021,290-295

12. Yang Liu, Lei Zhang, Huan Yan, Zhiqiang Wang, Guoliang Sun, Xiao Song, Zhongmin Zhou,Bo Peng, Liwei Yan, Qingcui Wu, Wenhui Li*, and Xiangbing Qi* “Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors”, J. Med. Chem., 2021, 64 (20), 5973-6007.

13. Lei Zhang, Ye Zhang, Wenting Li, Xiangbin Qi,  “Total Synthesis of (-)-Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade” Angew. Chem. Int. Ed. 2019, https://doi.org/10.1002/anie.201900156.

14. Yu Zhou, Yuanxun Wang, Pengfei Li, Xi-Ping Huang, Xiangbing Qi, Yunfei Du, and Niu Huang. “Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor–Ligand Interactions” ACS Med. Chem. Lett., 2018, 9 (10), pp 1019–1024.

15. Chao Wei, Xiao Han, Danwei Weng, Qiru Feng, Xiangbing Qi, Jin Li & Minmin Luo. “Response dynamics of midbrain dopamine neurons and serotonin Interactions neurons to heroin, nicotine, cocaine, and MDMA” Cell Discovery， 4 : 60 (2018)  1019–1024.

16. Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens, and Uttam K. Tambar*. “Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)‐Lundurine?A” Angew. Chem. Int. Ed., 2018, 57, 6888-6891.

17. Rui Lin, Qiru Feng, Peng Li, Ping Zhou, Ruiyu Wang, Zhe Liu, Zhiqiang Wang, Xiangbing Qi, Nan Tang, Feng Shao, Minmin Luo, “A hybridization-chain-reaction-based method for amplifying immunosignals” Nature Methods, 2018 (4), 275

18. Xuekai Zhang, Gang Lu, Meng Sun, Madhu Mahankali, Yanfei Ma, Mingming Zhang, Wangde Hua, Yuting Hu, Qingbing Wang, Jinghuo Chen, Gang He, Xiangbing Qi*, Weijun Shen, Peng Liu, Gong Chen，“A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp 3 C? H arylation”， Nature Chemistry，2018（10）, 540-548

19. Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling Huang, Chao Wang, Wenjing Li, Jianping Ding, Yun Zhao, Fa-Xing Yu, Xiangbing Qi*, Lei Zhang，“Staurosporine targets the Hippo pathway to inhibit cell growth” Journal of Molecular Cell Biology, 2018, 10, 267-269

20. Yanli Wang, Yuze Sun, Ran Cao, Dan Liu, Yuting Xie, Li Li, Xiangbing Qi*, Niu Huang，“In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery” J. Med. Chem., 2017, 60 (20), pp 8552-8564

21. Shih-Chia Tso, Mingling Lou, Wen-Jun Gui , Cheng-Yang Wu, Jacinta L. Chuang,     Lorraine K. Morlock, Noelle S. Williams, R. Max Wynn, Xiangbing Qi* and David T. Chuang* “Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors” J. Med. Chem., 2017, 60 (3), 1142-1150.

22. Yaling Wu, Dingbin Tang, Na Liu, Wei Xiong, Huanwei Huang, Yang Li, Zhixiong Ma,          Haijiao Zhao, Peihao Chen, Xiangbing Qi and Eric Erquan Zhang. “Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals”, Cell Metabolism, 2017, 25 (1), 73-85.

23. Shih-chia Tso^*, Xiangbing Qi^*, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K. Tambar, R. Max Wynna, and David T. Chuang. , “Structure-based Design and Mechanisms of Allosteric Inhibitors for Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Kinase.” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 9728-9733. (* Equal Contribution)

24. Feng Cai, Xiaotao Pu, Xiangbing Qi, Joseph. M. Ready*. “Allenes in Asymmetric Catalysis: Asymmetric Addition of Boronic Acid to α-ketoesters Catalyzed by Allene-Containing Rhodium-Phosphine Catalyst”. J. Am. Chem. Soc., 2011, 133, 18066-18069.

25. Xiangbing Qi, Hongli Bao, Uttam K.Tambar*. “Total Synthesis of (±)-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine”, J. Am. Chem. Soc. 2011, 133, 10050-10053.

26. Hongli Bao, Xiangbing Qi, Uttam K.Tambar*. “Catalytic Enantioselective [2,3]-Rearrangements of Amine N-Oxides ”, J. Am. Chem. Soc. 2011, 133, 1206-1208.

27. Xiangbing Qi, Grant T. Rice, Manjinder S. Lall, Mark S. Plummer, M. Christina White* “Diversification of a β-lactam Pharmacophore via Allylic C–H Amination: Accelerating Effect of Lewis Acid co-catalyst”, Tetrahedron, 2010, 66, 4816-4826.

28. Xiaotao Pu, Xiangbing Qi, Joseph. M. Ready*. “Allenes in Asymmetric Catalysis: Asymmetric Ring Opening of meso-Epoxides Catalyzed by Allene-Containing Phosphine Oxides” J. Am. Chem. Soc. 2009, 131, 10364-10365.

29 Xiangbing Qi, Joseph. M. Ready*. “Synthesis of Cyclopentenones from Cyclopropanes and Silyl Ynol Ethers” Angew. Chem. Int. Ed. 2008, 47, 7068-7070.

30. Xiangbing Qi, Joseph. M. Ready*. “Copper-Promoted Cycloaddition of Diazocarbonyl Compounds with Copper Acetylides” Angew. Chem. Int. Ed. 2007, 46, 3242-3244.

Patents （專利）

1. Wenhui Li, Xiangbing Qi, Yang Liu, Zhiqiang Wang, Bo Peng, Lei Zhang，“Betulinic Acid Derivatives Inhibit Hepatitis B and D Virus and NTCP Transport”. In preparation.

2. Xiangbing Qi, Ting Han, Peihao Chen, Lu Lv, Yamei Li, Longzhi Cao, Qingcui Wu, Jiaojiao Li, “A molecular glue regulating CDK12-DDB1 interaction to trigger Cycl in K degradation” PCT/CN2020/095482

3. David T. Chuang, Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Uttam K. Tambar, R. Max Wynn “Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof” US20170001958A1

4. Wenhui Li, Xiangbing Qi, Huan Yan, Yang Liu, Zhiqiang Wang, Bo Peng, Lei Zhang，“Polymeric Bile Acid Derivatives Inhibit Hepatitis B and D Virus and NTCP Transport”. US20170266206A1

5. Niu Huang, Xiangbing Qi, Yanli Wang, Yuze Sun. “Kinase Inhibitors”，WO2017152842A1

6. Xiangbing Qi, Mingliang Lou, Enlong Wu, Peihao Chen, Qingcui Wu, “Dihydroxyphenyl Sulfonylisoindoline Derivatives”, WO2018095260A1

7. Erquan Zhang, Xiangbing Qi, Dapeng Ju, Haijiao Zhao, Long Mei, Zhiqiang Wang, Qingcui Wu, “Adenosine Analog and its use in Regulating the Circadian Clock” WO2018133854A1