王濤博士
- 基本信息
- 教育經(jīng)歷
- 工作經(jīng)歷
- 研究概述
- 發(fā)表文章
王濤 博士
北京生命科學(xué)研究所高級(jí)研究員
聯(lián)系電話 ：010-90726675
Tao Wang, Ph.D. Associate Investigator, NIBS, Beijing，China
E-mail：wangtao1006@nibs.ac.cn
教育經(jīng)歷
Education
2006年 美國(guó)約翰霍普金斯大學(xué)醫(yī)學(xué)院生物化學(xué)系，博士
Ph. D., Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD, USA
2000年 北京大學(xué)生物化學(xué)系，碩士
M.S., Biochemistry Department, Peking University, Beijing, P. R. China
1997年 南開(kāi)大學(xué)生物化學(xué)及分子生物學(xué)系，學(xué)士
B.S., Biochemistry and Molecular Biology Department, Nankai University, Tianjin, P. R. China
工作經(jīng)歷
北京生命科學(xué)研究所高級(jí)研究員
Associate Investigator, National Institute of Biological Sciences, Beijing, China
北京生命科學(xué)研究所研究員
Assistant Investigator, National Institute of Biological Sciences, Beijing, China
美國(guó)Fred Hutchinson癌癥研究中心，博士后
Postdoctoral Fellow, Division of Basic Science Fred Hutchinson Cancer Research Center, Seattle, WA, USA
美國(guó)約翰霍普金斯大學(xué)，博士后
Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA
2018-
2012-2018
2007-2011
2006-2007
研究概述
細(xì)胞內(nèi)各個(gè)細(xì)胞器包括內(nèi)質(zhì)網(wǎng)、線粒體和胞漿都存在質(zhì)量控制機(jī)制，破壞質(zhì)量控制的任何環(huán)節(jié)都會(huì)影響細(xì)胞穩(wěn)態(tài)，是細(xì)胞功能喪失。我們的實(shí)驗(yàn)室致力于以果蠅模型為主研究細(xì)胞器內(nèi)質(zhì)量控制的分子機(jī)制；各個(gè)質(zhì)量控制系統(tǒng)之間的協(xié)調(diào)互作以維持細(xì)胞健康。
1. 線粒體運(yùn)輸協(xié)同線粒體自噬維持了神經(jīng)元軸突中線粒體穩(wěn)態(tài)，對(duì)神經(jīng)元的生長(zhǎng)和生理功能維持至關(guān)重要。圍繞線粒體的質(zhì)量控制機(jī)制，我們的實(shí)驗(yàn)室致力于揭示線粒體選擇性順行和逆行運(yùn)輸?shù)姆肿訖C(jī)制；線粒體自噬及調(diào)控網(wǎng)絡(luò)，并在果蠅、小鼠、以及人源細(xì)胞等多種研究模式中研究線粒體質(zhì)量控制對(duì)神經(jīng)元生理功能維持的生理意義。
2. 細(xì)胞磷脂代謝依賴于線粒體和內(nèi)質(zhì)網(wǎng)之間的脂質(zhì)雙向交換，多種磷脂如磷脂酰乙醇胺的缺乏引起多重應(yīng)激信號(hào)。我們實(shí)驗(yàn)室致力于探索線粒體和內(nèi)質(zhì)網(wǎng)之間脂質(zhì)雙向交換的分子機(jī)制和生理功能，進(jìn)而對(duì)細(xì)胞器之間如何協(xié)同反應(yīng)以對(duì)抗各種壓力。
發(fā)表文章
1. Xie J., Han Y. and Wang T.* 2021. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. PLoS Genet. 17(5):e1009558.
2. Han Y., Zhuang N. and Wang T.* 2021. Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila. Cell Reports. 34(12):108875 (cover article).
3. Xu J., Zhao H. and Wang T.* 2020. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. PLoS Genet. 16(11):e1009172.
4. Zhao H. and Wang T.* 2020. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila. PLoS Genet. 16(10):e1009070.
5. Xiong L., Zhang L., Yang Y., Li N., Lai W., Wang F., Zhu X. and Wang T.*. 2020. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Cell Death Differ. 27(2): 646-661.
6. Xu Y. and Wang T.* 2019. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. Cell Rep. 27(5):1327-1333.
7. Zhao H., Wang J. and Wang T.* 2018. The V-ATPase V1 subunit A1 Is required for rhodopsin anterograde trafficking in Drosophila. Mol. Biol. Cell. 29(13):1640-1651. (cover article).
8. Ren S., Huang Z., Jiang Y. and Wang T.* 2018. dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. J. Cell Biol. 217(2):517-526.
9. Han Y., Xiong L., Xu Y., Tian T. and Wang T.* 2017. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Elife. 6:e29146.
10. Zhuang N., Li L., Chen S. and Wang T.* 2016. PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control. Cell Death Dis. 7(12):e2501.
11. Huang Z., Ren S., Jiang Y. and Wang T.* 2016. PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila. Cell Death Dis. 7:e2179
12. Xu Y. and Wang T.* 2016. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. J Cell Sci. 15;129(2):394-405.
13. Xu Y., An F., Borycz J.A., Borycz J., Meinertzhagen I.A. and Wang T.* 2015. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. PLoS Genet. 11(12):e1005764.
14. Kuo Y., Hang H., Cai T. and Wang T.* 2015. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Sci. Rep. 5:10339.
15. Huang Y., Xie J. and Wang T.* 2015. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS One. 10(12):e0144925.
16. Wu K., Liu J., Zhuang N. and Wang T.* 2014. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. FASEB Journal. 28(12):5111-21
17. Kuo Y., Ren S., Lao U., Edgar B.A., Wang T.* 2013. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death Dis. 3;4:e833.
18. Wang T.*, Blumhagen R., Lao U. Kuo Y. and Edgar B.A. 2012. LST8 regulates cell growth via Target-of-Rapamycin Complex2. Mol. Cell. Biol. 32(12):2203-2213 (cover article).
19. Wang T., WangX., Ni J., Von Lintig J. and Montell C.* 2012. The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. J Neurosci. 32: 3485-3491.
20. Wang X., Wang T., Jiao Y., Von Lintig J. and Montell C.* 2010. Requirement for an Enzymatic Visual Cycle in Drosophila. Curr. Biol. 20:93-102 (equal contribution of first two authors)
21. Wang T.* and Edgar B.A.* 2010. TOR signaling and cell death. The Enzymes. 28: 217-244 (Book Chapter)
22. Wang T., Lao U. and Edgar B.A. 2009. TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J. Cell Biol. 186: 703-711
23. Wang T., Wang X., Xie Q. and Montell C.* 2008. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 57, 56-68 (Cover article).
24. Liu Z., Wang X., Yu Y., Li X., Wang T., Jiang H., Ren Q., Jiao Y., Sawa A., Moran T., Ross CA., Montell C. and Smith W.W.* 2008. A Drosophila model for LRRK2-linked parkinsonism. Proc. Natl. Acad. Sci. USA. 105, 2693-2698
25. Wang T. and Montell C.* 2007. Phototransduction and retinal degeneration in Drosophila. Pflugers Arch. 454, 821-847. (review)
26. Liu C-H. Wang T. Postma M. Obukhov A.G. Montell C. and Hardie R.C.* 2007. In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila TRP channel. J Neurosci. 27, 604-615 (equal contribution of first two authors).
27. Wang T., Jiao Y. and Montell C.* 2007. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol. 177, 305-316.
28. Wang T. and Montell C.* 2006. A PI Synthase Required for a Sustained Light Response. J Neurosci. 26, 12816-12825.
29. Wang T., Jiao Y. and Montell C.* 2005. Dissecting independent channel and scaffolding roles of the Drosophila TRP channel. J. Cell Biol. 171, 685-694.
30. Wang T. and Montell C.* 2005. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid binding protein. J. Neurosci. 25, 5187-5194 (Cover article).
31. Wang T., Xu H., Oberwinkler J., Gu Y., Hardie R.C. and Montell C.* 2005. Light-activation, adaptation and cell survival functions of the Na+/Ca2+ exchanger, CalX Neuron 45, 367-378.
